What are the signs of male infertility, and when should I get tested?
Most causes of male infertility do not cause noticeable symptoms. Many men feel completely healthy and may not realize there is an issue until pregnancy does not occur.
Male infertility is the inability of a male to impregnate a fertile partner. This condition is typically diagnosed when a couple is unable to conceive after regular, unprotected sexual intercourse for six to 12 months, depending on the patients’ ages. Various factors can impact a male’s ability to conceive, including those that affect the production, function, or delivery of sperm.
In general, fertility testing is recommended if pregnancy has not occurred after 12 months of unprotected intercourse, or after 6 months if the female partner is over age 35.
Men with a history of testicular injury, prior surgery, infections, prostate issues, hormone disorders, or known genetic conditions may benefit from earlier evaluation, even if they are not currently trying to conceive.
Potential Causes of Male Infertility
Male infertility can stem from issues affecting sperm production, sperm function, or the delivery of sperm. Common causes include:
- Varicocele (testosterone injections)
- Azoospermia (obstructive or non-obstructive)
- Low sperm count (oligospermia)
- Poor sperm motility or morphology
- Hormonal imbalances (e.g., low testosterone)
- Genetic or chromosomal conditions
- Infections or structural blockages
- Lifestyle or environmental factors
- Unexplained infertility
Identifying the underlying cause through diagnostic testing is the first step toward determining appropriate treatment options.
What is a semen analysis, and why does it matter?
A semen analysis is typically the starting point in evaluating male fertility. It provides critical information about sperm health and overall reproductive potential.
Semen Analysis: An assessment of male fertility begins with a semen analysis to evaluate sperm count, motility (i.e., movement), morphology (i.e., shape), the volume of seminal fluid, and pH levels.
The test measures:
- Sperm count: The number of sperm present in the sample
- Motility: How well sperm move
- Morphology: The size and shape of sperm
- Volume: The amount of semen produced
- pH levels: Which may affect sperm function
A semen analysis is the most common and useful testing method for male infertility. The test enables your fertility doctor to assess various parameters of your sperm and semen, including sperm count, motility, and morphology. The semen that is tested in the analysis is generally provided by ejaculating into a sterile container.
Patients are typically advised to abstain from ejaculation for 2–5 days before testing to ensure accurate results. The process is simple, private, and essential for identifying potential fertility concerns. Results help determine whether additional testing or treatment may be necessary.
What other male fertility tests might be recommended?
Several diagnostic tests are used to evaluate the cause of male infertility. Urologists or fertility specialists perform these tests. Depending on semen analysis results and clinical findings, additional testing may include:
Medical History and Physical Examination
A comprehensive physical examination is usually performed to determine your overall health. A detailed health history allows your specialist to identify prior surgeries, infections, medications, lifestyle factors, or physical abnormalities — such as varicoceles — that may affect fertility.
Hormone Testing
Several hormones that influence male reproduction can be measured via a blood test, including testosterone, follicle-stimulating hormone (FSH), prolactin, and luteinizing hormone (LH). An imbalance in hormones can affect sperm quality and production. Hormonal testing can help determine whether an underlying endocrine condition is contributing to infertility.
Genetic Testing
This section should briefly explain that genetic testing may be recommended in some cases of azoospermia or recurrent IVF failure to check for chromosomal abnormalities or Y-chromosome microdeletions.
Testicular Ultrasound
Using sound waves, this imaging test creates images of the testicles and surrounding structures. A testicular ultrasound can help identify structural abnormalities, such as varicoceles (i.e., enlarged veins) in the scrotum, or testicular growths.
Post-Ejaculation Urinalysis
A condition called retrograde ejaculation occurs when semen travels backward into the bladder instead of exiting the penis. This test determines if sperm are present in urine collected immediately after ejaculation.
Anti-Sperm Antibody Testing
Sometimes, the immune system produces antibodies that target sperm, prohibiting their movement. This test evaluates the presence of anti-sperm antibodies by analyzing a semen sample.
Testicular Biopsy
A biopsy procedure may be used to extract a small amount of testicular tissue. An examination of sperm samples under a microscope can provide information about sperm production and sperm cell maturity.