How to Have a Successful Frozen Embryo Transfer: Tips from Dr. Jenna McCarthy

Preparing for a Frozen Embryo Transfer (FET) is an exciting and emotional milestone in your fertility journey. Whether this is your first transfer or your fifth, it’s completely natural to want to do everything you can to support a smooth, successful experience. 

Dr. Jenna McCarthy shares her top recommendations to help patients feel confident, prepared, and empowered every step of the way. 

Take Your Medications Exactly as Directed 

Your medication protocol is one of the most important pieces of a successful FET cycle. Each dose is carefully timed to ensure your body is hormonally synchronized with your transfer. 

Dr. McCarthy emphasizes: 

“Take all medications exactly as your doctor directs you and if you have questions, reach out.” 

 
Your care team wants you to feel informed and supported, so don’t hesitate to clarify instructions or ask for help if something feels confusing. 

Progesterone in Oil (PIO): Make Injections Easier on Your Body 

Many patients will be prescribed progesterone in oil, an essential medication that improves outcomes and supports early pregnancy. Yes, these injections can be uncomfortable. The good news? There are simple techniques to make them much more manageable: 

Before the Injection 

• Numb the skin. Use an ice pack or ask your care team about a lidocaine cream to anesthetize the area. 

• Warm the oil. Progesterone is thick. Warm it slowly by holding the vial in your hands or placing it in your bra for a few minutes.  

• • Important: Don’t microwave or heat it, gentle warmth only. 

After the Injection 

• Move the muscle. Walking, doing a few squats, or gently massaging the area can help reduce soreness and prevent lumps. 

• Apply heat. A warm compress can help the oil disperse more comfortably. 

Small adjustments can make a big difference in how your body tolerates this medication. 

Arrive on Transfer Day with a Full Bladder 

A comfortably full bladder helps your provider visualize the uterus more clearly on ultrasound, supporting a smoother and more precise embryo transfer. 

Aim for “comfortably full,” not painfully full. If you’re unsure how much water to drink, your team can help guide you. 

Prioritize Stress Reduction and Emotional Wellbeing 

Your mental and emotional wellness plays a meaningful role during this chapter of your journey. Finding ways to care for yourself can make the process feel more manageable and positive. 

Dr. McCarthy encourages patients to lean into activities that bring calm, joy, or grounding, such as: 

• Spending time with your animals 

• Gentle movement (stretching, walking, yoga) 

• Acupuncture 

• Massage 

• Listening to music 

• Journaling or meditation 

• Quiet time with a partner or friend 

Choose what genuinely supports your mind and body. There’s no right or wrong here. 

Remember the Bigger Picture 

Perhaps Dr. McCarthy’s most meaningful advice is this: 

“Hold the vision, trust the process.”