PGD/PGS (Pre-Implantation Genetic Diagnosis/ Pre-Implantation Genetic Screening)

IVFMD offers state-of-the-art genetic testing of embryos. For patients with genetic diseases, translocations, or those who are “older” or suffer from recurrent miscarriages, this technology can improve your chances of having a healthy baby.

PGD refers to situations in which a patient has a known genetic disease, or is a carrier for a disease, and the embryos are analyzed so that only unaffected embryos (those that don’t carry the genetic disorder) are transferred into a uterus.

PGS refers to the technique where embryos are examined to determine if they have a normal number of chromosomes (which should be 46).  In both PGD and PGS, a micromanipulator and laser are used to remove a small sample of cells for analysis.  Unlike prior methods of genetic testing, ALL chromosomes are analyzed (older technologies only examined a handful of chromosomes).  Embryos that are free of selected genetic diseases or that possess the normal number of chromosomes can be selected from a group of embryos for subsequent transfer. Although no technique is correct 100% of the time, these new technologies can significantly increase your odds of having a healthy baby.

If, for example, you are a genetic disease carrier (at risk for passing a genetically transmitted disease to your baby) or are affected by a specific genetic disease (you actually have the disease), IVFMD can test your embryos to screen out (eliminate) those that might be affected or those that might even be potential carriers (carrying only one copy of the genetic mutation).

Another use of this technology is for “advanced maternal age” (generally defined as over age 34).  As maternal age increases, the incidence of chromosomal abnormalities increases, resulting in decreased fertility, an increased risk of spontaneous pregnancy loss (miscarriage), and infants born with chromosomal abnormalities such as Down Syndrome.  The PGS technique allows our laboratory to select embryos that have the highest chance of having the correct number of chromosomes from the pool of embryos available for transfer.  There is preliminary evidence to suggest that aneuploidy screening (screening embryos for the normal number of chromosomes) in certain couples may improve their odds of IVF success by:

  1. Selecting embryos with an improved potential for implantation (increased chance of pregnancy).
  2. Selecting embryos with a decreased rate of spontaneous loss (decreased chance of miscarriage).
  3. Decreasing the chance of a live born child with chromosomal abnormalities (decreased chance of a baby born with particular birth defects).